Addisons disease in humans psychosis
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Background
There have been few reports of psychosis as a prominent feature of inadequate glucocorticoid replacement in panhypopituitarism. Initial presentations are often attributed to an undiagnosed psychiatric disorder or vascular collapse during the crisis state causing delirium.1 Patients often end up being treated with antipsychotics over prolonged periods with minimal benefits while the reversible cause of psychosis remains hidden and comes to light with improvement in the patient’s condition with adequate steroids replacement.
Case Presentation
A year-old female with a past medical history of panhypopituitarism and blindness secondary to a resected pituitary tumor ten years earlier presented with complaints of decreased oral intake, vomiting, altered mental status, confusion, and hallucinations for the past two days. History obtained from the family noted that she was admitted to another hospital for vomiting and presumed sepsis three months prior. At that time, she was
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The Neuropsychiatric Aspect of Addison’s Disease
Abstract
Chronic adrenal insufficiency, known as Addison’s disease, presents with a constellation of symptoms and signs. The neuropsychiatric aspect of this condition is not fully understood and not much has been documented about it in the English literature. This article presents a case of a year old male patient who presented initially with depression after a recent life stressor. After his condition escalated and therapy continued to fail, the medical team revised its diagnosis to Addison’s disease. Neuropsychiatric symptoms could be the first presentation of Addison’s disease, and thus should be kept in mind whenever such a case presents to the physician.
Keywords: Addison’s disease, neuropsychiatric symptoms, depression, psychosis
INTRODUCTION
Addison’s disease (AD) is a medical condition characterized by chronic adrenal insufficiency leading to failure of glucocorticoid secretion.1 Although AD has a constellation of car
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Psychotic Disorder as the First Manifestation of Addison Disease: A Case Report
Abstract
Introduction
Addison disease is a relatively uncommon endocrine disease resulting from adrenal insufficiency. Psychiatric symptoms are among its rare primary and particularly isolated clinical symptoms. This report presents a case with adrenal insufficiency manifested by the psychotic syndrome.
Case Presentation
A year-old Iranian female with a history of immune thrombocytopenic purpura (ITP) and asthma since childhood presented with a month history of progressive depression with insomnia and mardröm symptoms. After being prescribed haloperidol, clomipramine, and clonazepam for eight months, abdominal pain and vikt loss due to anorexia started. Her physical examination showed skin hyperpigmentation in the elbow, knee, ankle, and buccal mucosa. Physical examination and initial laboratory tests suggested adrenal insufficiency. Addison disease was confirmed according to the laboratory test