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Efficacy and Safety of a Bovine-Associated Staphylococcus aureus Phage Cocktail in a Murine Model of Mastitis.
PubMed
Breyne, Koen; Honaker, Ryan W; Hobbs, Zachary; Richter, Manuela; Żaczek, Maciej; Spangler, Taylor; Steenbrugge, Jonas; Lu, Rebecca; Kinkhabwala, Anika; Marchon, Bruno; Meyer, Evelyne; Mokres, Lucia
2017-01-01
Overuse of antibiotics is a major problem in the treatment of bovine mastitis, and antibiotic treatment is frequently non-curative, thus alternative treatments are necessary. The primary aim of this study was to evaluate the efficacy of a purified phage cocktail for treatment of bovine Staphylococcus aureus mastitis in a well-defined mouse model. Candidate phages were selected based on their in vitro performance and subsequently processed into an optimally composed phage cocktail. The highest scoring phages were further tested for efficacy and resistance suppression in broth and raw milk, with and without supplemental IgG. As these in vitro results displaye
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Investigating Typhoon Induced River-Surge Interactions in the Tamsui Estuary, Taiwan.
NASA Astrophysics Data System (ADS)
Maskell; J. H.; Grieser, J.; Rodney, J.; Howe, N. J.
2016-02-01
It is increasingly important to understand the combined influence of the main drivers of coastal risk due to sea level rise and the potential increase in extreme weather events. An Asian Basin stochastic typhoon set was used to force a storm surge model of Taiwan to investigate the interaction between storm surge and high river discharges (50, 100 and 200 year return period discharges) in the Tamsui River. Taiwan is a mountainous country leading to the combined risk of surge and high river discharge occurring simultaneously in estuary regions. The typhoon tracks were selected using a Hurricane Surge Index (Kantha, 2006) and cross the northern tip of Taiwan with maximum sustained winds (Vmax) between 51 m/s and 75 m/s (Cat 3-5). Peak surge elevations in the Tamsui River range from 5.7 m to 10.3 m
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